Stroke

New Stroke Findings from University Hosp Published

Published in Blood Weekly, December 29th, 2011

2011 DEC 29 -- According to the authors of a study from Essen, Germany, "Hyperlipidemia is a highly prevalent risk factor for ischemic stroke. Its impact on brain injury and blood-brain barrier permeability, so far, has not been assessed in animal models of ischemic stroke."

"Wild-type and apolipoprotein E-/- mice, fed with normal or cholesterol-rich high-fat food, were subjected to 30 minutes of middle cerebral artery occlusion. Ischemic injury, brain edema, IgG extravasation, lipid peroxidation, calpain-1/2, matrix metalloproteinase-2/9, and RhoA activation, and occludin expression were evaluated 24 hours after reperfusion. Cholesterol-rich food, but not...

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Source: Blood Weekly (2011-12-29)

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