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Sepsis

Research from University of Tokyo Has Provided New Data on Sepsis

Published in Blood Weekly, December 29th, 2011

2011 DEC 29 -- In this recent report published in the Journal of Surgical Research, researchers in Tokyo, Japan conducted a study "To examine the effects of pioglitazone, peroxisome proliferator-activated receptor-gamma (PPAR-gamma), on mortality and omental adipocyte function in mice with cecal ligation and puncture (CLP). Male mice were assigned to receive (1) vehicle/sham-operation, (2) pioglitazone/CLP, or (3) vehicle/CLP."

"Pioglitazone was injected intraperitoneally for 7 d before operation. Serum and omental tissue were collected before, 24, and 48 h after CLP. Serum levels of adiponectin, cytokine, and chemokine were measured with ELISA. mRNA...

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