Ischemia

Study Results from Kyoto University Provide New Insights into Ischemia

Published in Blood Weekly, January 19th, 2012

2012 JAN 19 -- "Ischemia/reperfusion (I/R) is an important cause of acute renal failure. Recent studies have shown that the complement system mediated by the mannan-binding protein (MBP), which is a C-type serum lectin recognizing mannose, fucose and N-acetylglucosamine residues, plays a critical role in the pathogenesis of ischemic acute renal failure," researchers in Kyoto, Japan report.

"MBP causes complement activation through the MBP lectin pathway and a resulting complement component, C3b, is accumulated on the brush borders of kidney proximal tubules in a renal I/R-operated mouse kidney. However, the initial step of the complement activation has not...

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Source: Blood Weekly (2012-01-19)

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