Sepsis
Guy's & St Thomas' NHS Foundation Trust Details Research in Sepsis
Published in Blood Weekly, February 2nd, 2012
2012 FEB 2 -- "Activated protein C (APC) induces release of microparticles (MP) from primary physiological cells, which are found in patients undergoing treatment with recombinant human APC (rhAPC) for severe sepsis. We hypothesised that APC on these circulating MPs activate endothelial protease-activated receptor 1 (PAR1) to induce anti-apoptotic and anti-inflammatory properties that can improve patient outcome," scientists writing in the journal Critical Care report.
"This was an experimental study on clinical samples in an intensive care setting, and included patients with severe sepsis who fulfilled criteria for treatment with rhAPC. The number...
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Source: Blood Weekly (2012-02-02)
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