Serine Endopeptidases

Reports from University of Illinois Highlight Recent Research in Serine Endopeptidases

Published in Blood Weekly, February 2nd, 2012

2012 FEB 2 -- "Factor XI deficiency is associated with a bleeding diathesis, but factor XII deficiency is not, indicating that, in normal hemostasis, factor XI must be activated in vivo by a protease other than factor XIIa. Several groups have identified thrombin as the most likely activator of factor XI, although this reaction is slow in solution," scientists writing in the journal Blood report.

"Although certain nonphysiologic anionic polymers and surfaces have been shown to enhance factor XI activation by thrombin, the physiologic cofactor for this reaction is uncertain. Activated platelets secrete the highly anionic polymer polyphosphate, and our...

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Source: Blood Weekly (2012-02-02)

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