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Proinsulin

Reports Summarize Proinsulin Research from University of Strasbourg

Published in Blood Weekly, February 9th, 2012

2012 FEB 9 -- "The loss of graft function after intraportal islet transplantation is likely multifactorial involving allogeneic rejection, recurrent autoimmunity, graft exhaustion due to a marginally implanted islet mass, immunosuppressant toxicity, and impaired beta-cell regeneration. Because early markers of the loss of beta-cell mass or function are lacking, monitoring of islet function remains a challenging issue," scientists in Strasbourg, France report.

"We have reported herein monitoring of membrane procoagulant microparticles (MPs) as markers of cell stress in the plasma of three recipients with various clinical histories. Early kinetics of...

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