Research from Kyushu University Broadens Understanding of Nucleoproteins

2012 FEB 9 -- A new study, "Isolation of nuclei from skeletal muscle satellite cells and myofibers for use in chromatin immunoprecipitation assays," is now available. "Studies investigating mechanisms controlling gene regulation frequently examine specific DNA sequences using chromatin immunoprecipitation (ChIP) assays to determine whether specific regulatory factors or modified histones are present. While use of primary cells or cell line models for differentiating or differentiated tissue is widespread, the ability to assess factor binding and histone modification in tissue defines the events that occur in vivo and provides corroboration for studies in cultured cells,"...

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