Intercellular Signaling Peptides and Proteins
Research Data from Harvard University Update Understanding of Intercellular Signaling Peptides and Proteins
Published in Blood Weekly, March 1st, 2012
2012 MAR 1 -- According to the authors of recent research from Boston, Massachusetts, "The proinflammatory cytokine IL-6 plays an important role in controlling T-cell differentiation, especially the development of Th17 and regulatory T cells. To determine the function of IL-6 in regulating allograft rejection and tolerance, BALB/c cardiac grafts were transplanted into wild-type or IL-6-deficient C57BL/6 mice."
"We observed that production of IL-6 and IFN-' was upregulated during allograft rejection in untreated wild-type mice. In IL-6-deficient mice, IFN-' production was greater than that observed in wild-type controls, suggesting that IL-6 production...
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Source: Blood Weekly (2012-03-01)
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