Study Results from Graduate School of Engineering Broaden Understanding of Biomedical Engineering

2012 MAR 1 -- Research findings, "Artificial extracellular matrix proteins containing phenylalanine analogues biosynthesized in bacteria using T7 expression system and the PEGylation," are discussed in a new report. According to the authors of recent research from Nagoya, Japan, "In vivo incorporation of phenylalanine (Phe) analogues into an artificial extracellular matrix protein (aECM-CS5-ELF) was accomplished using a bacterial expression host that harbors the mutant phenylalanyl-tRNA synthetase (PheRS) with an enlarged binding pocket. Although the Ala294Gly/Thr251Gly mutant PheRS (PheRS* *) under the control of T5 promoter allows incorporation of some Phe analogues into a...

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