Genetic Predisposition

GSTM1 and GSTM2 Gene Deletions Do Not Increase Breast Cancer Risk

Published in Breast Cancer Weekly, February 5th, 2000

Glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) genes are known to play a role in the metabolism of many ubiquitous carcinogens, but it appears that lack of these genes does not increase the risk of breast cancer.

M. Garciaclosas and colleagues sought to determine if GSTM1 and GSTT1 might protect against breast cancer because of their role in metabolizing carcinogens. They studied 466 women with incident cases of breast cancer against 466 matched controls. The women were diagnosed between May 1989 and May 1994.

No increased breast cancer risk was found in the GSTM1 genotype (Odds ratio (OR)=1.05 [95% confidence interval (CI)=0.80-1.37] )...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Breast Cancer Weekly

Source: Breast Cancer Weekly (2000-02-05)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry