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Cancer Gene Therapy Week

Susan Hasty, Publisher

Table of Contents . . . July 28th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Gene Therapy Week | Other Publications

Oncology - Methioninase gene therapy causes apoptosis in bcl-2-expressing lung cancers

Virology - A mosaic virus strategy may improve adenoviral tropism in human gene therapy

Cancer Gene Therapy - Phase I/II trial results look good so far in breast cancer patients

Gynecology - Gene therapy reverses the malignant phenotype of ovarian cancer cells

Transduction - Endogenous p21 status predicts human tumor cell response to wild-type genes

Vector Development - The oncolytic effect of parvovirus H1 is routed through heat shock protein

Brain Tumors - Cladribine and 2-chloro-adenosine induce apoptosis of human astrocytoma cells

Brain Tumors - Loss of GFAP expression in astrocytomas does not contribute to tumor development

Breast Cancer - BRCA2 has a role in recombination-mediated double-strand DNA break repair

Breast Cancer - Breast cancer may be initiated by estrogen exposure, which causes DNA DSBs

Breast Cancer - Calcium HA can amplify the pathological process in breast cancer

Breast Cancer - Elevated hdm2 levels play a role in development of ERalpha(+ve) breast tumors

Breast Cancer - HRG/M sequences are sufficient to sensitize MCF-7 cells to doxorubicin

Breast Cancer - Prolactin may be a novel therapeutic target for the treatment of breast cancer

Breast Cancer - The effects of metals may be mediated through the hormone-binding domain

Cancer Diagnosis - Molecular methods of diagnosing cancer offer great advantages

Cell Biology - Hypoxia attenuates the p53 response to cellular damage

Cervical Cancer - Genetic analysis identifies putative tumor suppressor sites

Cervical Cancer - Papillomaviruses can be models to study the mechanism of CpG methylation

Colon Cancer - Activation of c-Jun-N-terminal-kinase is crucial for a cell cycle arrest

Colon Cancer - Genetic testing for high-risk colon cancer patients has improved risk assessment

Colon Cancer - KLF4, a cell cycle checkpoint protein, can reduce tumorigenicity of colon cancer

Colon and Lung Cancer - MBD1, MBD2 and CGBP genes may have only a limited role in human tumorigenesis

Gastric Cancer - Tumor suppressor genes show a gene type-specific methylation profile

Gastric Malignancy - Expression of the bacterial virulence gene cagA was repressed by acid exposure

Gastroenterology - Pancreatic tumors become susceptible to toxin when made to express IL-13Ralpha2

Glioma - Interferon-beta gene transfer accompanied by dendritic cells inhibits cancer

Hepatology - Apoptotic body engulfment by a human stellate cell line is profibrogenic

Human Genome - Global gene variation map key to finding cures

Liver Cancer - Hepatocellular carcinoma is controlled with enzyme inhibitors

Liver Cancer Model - DNA damage response is attenuated in TGFalpha/c-myc mice

Lung Cancer - p53 mutation was not related to patient survival in some lung cancer patients

Melanocytic Neoplasia - Genomic analysis can provide insight into progression of melanocytic neoplasms

Melanoma - Gene-expression profiling in human cutaneous melanoma profiles genetic changes

Melanoma - Genetically engineered models will help understand UV radiation and melanoma

Melanoma - Moles or nevi may be senescent clones of melanocytes

Melanoma - Taurolidine has differing effects on adherent and floating melanoma cells

Mutagenesis - Somatic mutation in V-H genes leads the way from MGUS to multiple myeloma

Orolaryngeal Cancer - EH polymorphisms are important in the risk of orolaryngeal cancer in Caucasians

Ovarian Carcinoma - Distinct pathways of carcinogenesis may exist for serous carcinoma of the ovary

Prostate Cancer - Neural adhesion molecule is upregulated in perineural prostate cancer invasion

Thymic Tumors - Chromosomal imbalances may cause aggressive behavior in some type A thymomas

Thyroid Cancer - Downregulation of PPARgamma is a key event in many types of thyroid neoplasia

Tobacco-Related Cancer - CYP2A6 polymorphisms have been linked to reduced risk of tobacco-related cancers

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