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Cancer Gene Therapy Week

Susan Hasty, Publisher

Table of Contents . . . December 15th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Gene Therapy Week | Other Publications

Melanoma - Interferons are potent stimulators of interferon-alpha inducible genes

Oncology - ONYX-015-based replicating adenoviruses can deliver prodrug converting enzyme

Drug Development - A new fusion gene causes direct and bystander killing of sarcomas

Drug Resistance - Targeted gene therapies could exploit or overcome tumor hypoxia

Acute Myeloid Leukemia - Progenitor cell involvement predicts response to induction chemotherapy in AML

Antitumor Agent - TT-232: a somatostatin structural derivative as a potent antitumor drug

Bladder Cancer - The PATCHED/Sonic Hedgehog signaling pathway in superficial bladder cancer

Breast Cancer - Association studies may be more efficient that population-based studies

Breast Cancer - Involvement of a novel fast I-Na current in breast cancer cell invasion

Breast Cancer - Phenotypic effects of heterozygosity for a BRCA2 mutation

Breast Cancer - Raloxifene inhibits estrogen-induced up-regulation of telomerase activity

Cancer Cell Growth - Selected isothiocyanates rapidly induce growth inhibition of cancer cells

Cancer Therapy - Positive data on rhIGFBP-3 published

Carcinogens - Alteration of keratinocyte differentiation and senescence by dioxin

Cervical Cancer - Oncogenic potential varies moderately within the high-risk group of HPVs

Chemotherapy - The role of nucleoside transporters in resistance to cancer chemotherapy

Chordomas - Mapping of candidate region for chordoma development to 1p36.13 by LOH analysis

Chronic Myelogenous Leukemia - Involvement of Akt kinase in the action of STI571 on CML cells

Colon Cancer - Adapalene may be an effective adjunctive therapy for colon cancer in vivo

Colon Cancer - Familial hereditary mixed polyposis syndrome

Colon Cancer - Macrophage inhibitory cytokine-1: A novel biomarker for p53 pathway activation

Colorectal Cancer - CEA-producing cell-specific oncolytic adenovirus, OV798, for colorectal cancer

Colorectal Cancer - Hereditary nonpolyposis colorectal cancer and related conditions

Colorectal Cancer - Reduced accumulation of specific microRNAs in colorectal neoplasia

DNA Damage - The role of p53 in chemosensitivity and radiosensitivity

Drug Resistance - E-cadherin-dependent intercellular adhesion enhances chemoresistance

Endometrial Cancer - 11q23-24 loss is associated with chromosomal instability in endometrial cancer

Epstein-Barr Virus - Germinal center B cells appear to be those susceptible to EBV transformation

Esophageal Cancer - Molecular detection of free cancer cells in pleural lavage fluid

Fallopian Tube Cancer - Clinical aspects, histopathology, and genetics of fallopian tube cancer

Folate Deficiency - Folate deficiency, mismatch repair-dependent apoptosis, and human disease

GI Cancer - Role of GI hormones in the proliferation of normal and neoplastic tissues

GI Cancer - The emerging role of the hedgehog signaling pathway in upper GI cancers

Head and Neck Cancer - Prevalence of human papillomavirus in head and neck squamous cell carcinomas

Hereditary Cancer - The von Hippel-Lindau gene, kidney cancer, and oxygen sensing

Leukemia - Down-regulation of TNF-alpha receptors by conophylline in T-cell leukemia cells

Leukemia - Inhibition of JNK signaling diminishes early cellular stress-induced apoptosis

Leukemia - Mechanisms of STI571 resistance to Philadelphia chromosome-associated leukemias

Leukemia - TEL-related FTKs may stimulate the repair of DNA damaged by idarubicin

Lung Cancer - Aberrant cycin D2 methylation may play role in lung cancer pathogenesis

Lung Cancer - Methylation of genes in the upper aerodigestive tract epithelium of smokers

Lymphoma - High frequency of genetic aberrations in enteropathy-type T-cell lymphoma

Measles - Attenuated measles virus, GM-CSF expression enhances neutrophil antitumor action

Melanoma - Bcl-X proteins are important for control of apoptosis in malignant melanoma

Non-Hodgkin Lymphoma - Centrosome aberrations may be a mechanism for chromosomal instability in NHL

Oral Cancer - Alpha(Nu)beta6-Fyn signaling promotes oral cancer progression

Oral Carcinoma - SDF-1/CXCR4 signaling may be involved in of lymph node metastasis

Ovarian Cancer - Alternative pathways of ovarian apoptosis: Death for life

Ovarian Cancer - Nucleotides play unique role in regulation of ovarian cancer cells

Ovarian Cancer - Researchers identify biomarkers for ovarian cancer

Patents - Patent on p53 therapy upheld in Europe

Premature Senescence - Bcl-2 activates a program of premature senescence in human carcinoma cells

Prostate Cancer - From the gene to the clinic: prostate cancer death can now be an exception?

Proteolysis - When protein destruction runs amok, malignancy is on the loose

Retinoids - Retinoids in cancer therapy and chemoprevention: Promise meets resistance

Staff Safety - Study demonstrates biological uptake of chemotherapy drugs

Stem-Cell Transplantation - Safety and efficacy of nonmyeloablative SCT reviewed

Thyroid Carcinoma - Maspin is a special feature of papillary thyroid carcinoma

Tumor Suppressor - Puma is an essential mediator of p53-dependent/independent apoptotic pathways

Tumor Suppressors - BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks

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