Drug Development
Antisense oligonucleotide LErafAON enhances the work of standard chemotherapy
Published in Cancer Gene Therapy Week, June 14th, 2004
"Raf-1 protein serine/threonine kinase plays an important role in cell proliferation and cell survival. We have previously described a novel cationic liposome-entrapped formulation of raf antisense oligodeoxyribonucleotide (LErafAON) and its use as a radiosensitizer. The aim of this study was to examine the effect of combination of LErafAON and a chemotherapeutic agent on growth of human prostate (PC-3) and pancreatic tumor xenografts in athymic mice (Aspc-1 and Colo 357)," investigators in the United States report.
"In PC-3 tumor-bearing mice, administration of a...
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