Published in Cancer Gene Therapy Week, November 15th, 2004
"The term epigenetic refers to a heritable change in gene expression that is mediated by mechanisms other than alterations in the primary nucleotide sequence. DNA methylation at cytosine bases that are located 5' to guanosine within a CpG dinucleotide is the main epigenetic modification in humans. Patterns of DNA methylation are profoundly deranged in human cancer and comprise genome-wide losses as well as regional gains in DNA methylation," scientists in Spain report.
"Hypermethylation of CpG islands within gene promoter regions is associated with transcriptional...
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