Drug Development

Epigenetic changes in hematopoietic malignancies offer novel treatment tactics

Published in Cancer Gene Therapy Week, November 15th, 2004

Epigenetic changes in hematopoietic malignancies offer novel treatment tactics.

"The term epigenetic refers to a heritable change in gene expression that is mediated by mechanisms other than alterations in the primary nucleotide sequence. DNA methylation at cytosine bases that are located 5' to guanosine within a CpG dinucleotide is the main epigenetic modification in humans. Patterns of DNA methylation are profoundly deranged in human cancer and comprise genome-wide losses as well as regional gains in DNA methylation," scientists in Spain report.

"Hypermethylation of CpG islands within gene promoter regions is associated with transcriptional...

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Source: Cancer Gene Therapy Week (2004-11-15)

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