Apoptosis
AMID may be a p53-downstream gene involved in tumorigenesis
Published in Cancer Gene Therapy Week, November 15th, 2004
"AMID, also called PRG3, is an AIF-homologous and mitochondria-associated protein that has been implicated in caspase-independent apoptosis. In this report, we demonstrated that human AMID gene promoter was activated by p53 in reporter gene assays. Chromatin immunoprecipitation experiments indicated that p53 could bind to human AMID promoter," investigators in Peoples Republic of China reported.
"Deletion mutagenesis indicated that human AMID promoter contains two p53-responsive elements. Furthermore, expression array analysis indicated that human AMID mRNA expression was downregulated in a...
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