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Gene Vaccine

Semliki Forest virus-based vector elicits a strong reaction to tumor antigen

Published in Cancer Gene Therapy Week, May 16th, 2005

Semliki Forest virus-based vector elicits a strong reaction to tumor antigen.

"Recombinant Semliki Forest virus (rSFV) enables high-level, transient expression of heterologous proteins in vivo, and is believed to be a superior vector for genetic vaccination, compared with the conventional DNA plasmid. Nonetheless, the efficacy of rSFV-based vaccine in eliciting human immune responses has not been tested," researchers in the Peoples Republic of China report.

"We used a Trimera mouse model, consisting of lethally irradiated BALB/c host reconstituted with nonobese diabetes/severe combined immunodeficiency (NOD/SCID) bone marrow plus human peripheral...

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