Leukemia

Role for PML3 in centrosome duplication and genome stability defined

Published in Cancer Gene Therapy Week, May 16th, 2005

The role of promyelocytic leukemia gene (PML) in centrosome duplication and genome stability has been defined.

According to a study from the United States, "PML, which is disrupted by the chromosomal translocation t(15;17) in acute promyelocytic leukemia (APL), encodes a multifunctional protein involved in several important cellular functions."

"Herein, we demonstrate that PML is localized to centrosomes and that PML deficiency leads to centrosome amplification. By using PML isoform-specific antibodies, we found PML-3-specific association with the centrosome and the pole of the mitotic spindle. PML3 deficiency leads to clysregulation of the...

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Source: Cancer Gene Therapy Week (2005-05-16)

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