Published in Cancer Gene Therapy Week, May 16th, 2005
According to a study from the United States, "PML, which is disrupted by the chromosomal translocation t(15;17) in acute promyelocytic leukemia (APL), encodes a multifunctional protein involved in several important cellular functions."
"Herein, we demonstrate that PML is localized to centrosomes and that PML deficiency leads to centrosome amplification. By using PML isoform-specific antibodies, we found PML-3-specific association with the centrosome and the pole of the mitotic spindle. PML3 deficiency leads to clysregulation of the...
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