Gene Transfer
Co-delivered mutant IkappaBalpha enhances suicide gene therapy
Published in Cancer Gene Therapy Week, June 6th, 2005
Published research from Japan indicates that "to improve the effectiveness of herpes simplex virus (HSV) thymidine kinase/ganciclovir (HSV-tk/GCV) suicide gene therapy, the replication-defective HSV vector TOIkappaB expressing both HSV-TK and a mutant form of the nuclear factor (NF)-kappaB inhibitor IkappaBalpha (IkappaBalphaM) was developed."
"TOIkappaB was constructed by recombining the IkappaBalphaM gene into the U(L)41 locus of a replication-defective lacZ expression vector, TOZ.1. Expression of IkappaBalphaM was confirmed by Western blotting, and the ability of the mutant protein to...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Gene Therapy Week
More Articles from Cancer Gene Therapy Week
- Enzymology
uPAR antisense oligonucleotide prevents prostate cancer bone metastasis in mice - Oncology
Corticosteroid adversely affects HSV-tk/ganciclovir suicide gene therapy - Oncology
Dominant-negative growth factor receptor fights gastric cancer progression - Vector Development
Complex mosaicism boosts the infectivity of adenovirus type 5-based vectors - Acute Myeloid Leukemia
Dominant negative effects of AML1/ETO may be important for AML pathogenesis - Apoptosis
Boswellic acid acetate induces apoptosis via caspase-mediated pathways - More from this issue of Cancer Gene Therapy Week
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
