Esophageal Cancer

Functional polymorphisms of SLC11A1 associated with risk of esophageal cancer

Published in Cancer Gene Therapy Week, July 4th, 2005

Functional polymorphisms of SLC11A1 were associated with a higher risk of esophageal cancer among the South African Colored population.

According to a study from South Africa, "Several environmental factors have been implicated in the etiology of esophageal cancer (EC). The purpose of this study was to assess the likelihood that variation in the SLC11A1 gene contributes to EC susceptibility, possibly due to its role in inflammation and iron metabolism."

"The regions of the gene containing potential functional polymorphisms, including the promoter region and exon 2, were investigated. The study cohort included 105 EC South African Colored patients...

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Source: Cancer Gene Therapy Week (2005-07-04)

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