Vector Development
Bifidobacterium infantis transmits suicide gene therapy to melanoma cells
Published in Cancer Gene Therapy Week, July 4th, 2005
Researchers in the People's Republic Of China conducted a study "to construct a Bifildobacterium infantis/CD targeting gene therapy system and observe the antitumor effect of cytosine deaminase/5-fluorocytosine (CD/5-FC) suicide gene therapy system mediated by Bifidobacterium infantis on melanoma in vitro and in vivo. A recombinant CD/pGEX-1LamdaT plasmid was transfected into Bifidobacterium infantis by electroporation."
"Bifidobacterium infantis transfected by recombinant CD/pGEX-1LamdaT plasmid was incubated with 5-FC anaerobically. Then...
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