Cancer Gene Therapy
Combination antisense oligodeoxyribonucleotide-radiation therapy evaluated
Published in Cancer Gene Therapy Week, April 17th, 2006
"Raf proteins are key elements of growth-related cellular signaling pathways and are a component of cancer cell resistance to radiation therapy. Antisense oligonucleotides to c-raf-1 permit highly selective inhibition of the gene product and offer a strategy for sensitizing cancer cells to radiation therapy.
"In this dose escalation study, we evaluated the safety of combined liposomal formulation of raf antisense oligonucleotide (LErafAON) and radiation therapy in patients...
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