Published in Cancer Gene Therapy Week, November 6th, 2006
"The mda-7 is a member of the interleukin-10 cytokine family and a novel tumor suppressor gene. Adenoviral-mediated mda-7 (Ad-mda7) gene transfer has tumor-specific growth inhibitory and proapoptotic effects in a broad spectrum of cancer cells," wrote D. Bocangel and colleagues, Introgen Therapeutic.
"In breast cancer cells, adenoviral-induced mda-7 expression triggers antiproliferative effects by downregulation of survival signals, such as Bcl-2 and...
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