Cancer Gene Therapy

Breast cancer cell combinatorial synergy is induced by adenoviral mediation

Published in Cancer Gene Therapy Week, November 6th, 2006

According to recent research from the United States, combinatorial synergy is induced by adenoviral-mediated melanoma differentiation-associated gene-7 (mda-7) and Herceptin in Her-2+breast cancer cells.

"The mda-7 is a member of the interleukin-10 cytokine family and a novel tumor suppressor gene. Adenoviral-mediated mda-7 (Ad-mda7) gene transfer has tumor-specific growth inhibitory and proapoptotic effects in a broad spectrum of cancer cells," wrote D. Bocangel and colleagues, Introgen Therapeutic.

"In breast cancer cells, adenoviral-induced mda-7 expression triggers antiproliferative effects by downregulation of survival signals, such as Bcl-2 and...

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Source: Cancer Gene Therapy Week (2006-11-06)

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