Cancer Gene Therapy
Korea Institute of Radiological and Medical Science details research in cancer gene therapy
Published in Cancer Gene Therapy Week, December 25th, 2006
Data detailed in "Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: effect of p53" have been presented. "Loss of p53 tumor suppressor facilitates acquisition of telomerase activity. In fact, both p53 inactivation and telomerase activation are frequently found in human cancers. p53 inactivation, however, eliminates or attenuates the biological responses to telomerase inhibition and the eventual telomere erosion," investigators in Seoul, Korea report.
"We show that telomere erosion can increase the susceptibility to radiation, irrespective of p53 status. Both telomerase inhibition and critically shortened...
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