Leukemia Gene Therapy

Findings from University of Cambridge advance knowledge in leukemia gene therapy

Published in Cancer Gene Therapy Week, July 20th, 2009

"The Lmo2 gene encodes a transcriptional cofactor critical for the development of hematopoietic stem cells. Ectopic LMO2 expression causes leukemia in T-cell acute lymphoblastic leukemia (T-ALL) patients and severe combined immunodeficiency patients undergoing retroviral gene therapy," researchers in Cambridge, the United Kingdom report.

"Tightly controlled Lmo2 expression is therefore essential, yet no comprehensive analysis of Lmo2 regulation has been published so far. By comparative genomics, we identified 17 highly conserved noncoding elements, 9 of which revealed specific acetylation marks in chromatin-immunoprecipitation and microarray (ChIP-chip) assays performed...

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Source: Cancer Gene Therapy Week (2009-07-20)

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