Antisense Technology
Researchers from University of Bologna, Department of Biochemistry discuss findings in antisense technology
Published in Cancer Gene Therapy Week, March 1st, 2010
New investigation results, 'DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus,' are detailed in a study published in Nucleic Acids Symposium Series. "Top1 inhibition by camptothecin (CPT) perturbs RNA polymerase II (Pol II) density at promoters and along transcribed genes suggesting an involvement of Top1 in Pol II pausing. Here, we demonstrate that Top1 inhibition favors Pol II escape from a promoter-proximal pausing site of the human HIF-1alpha gene in living cells," investigators in Bologna, Italy report.
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