Life Science
New data from Harvard University illuminate research in life science
Published in Cancer Gene Therapy Week, August 9th, 2010
Data detailed in 'Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo' have been presented. "The p53 homologs, p63 and p73, share approximately 85% amino acid identity in their DNA-binding domains, but they have distinct biological functions. Using chromatin immunoprecipitation and high-resolution tiling arrays covering the human genome, we identify p73 DNA binding sites on a genome-wide level in ME180 human cervical carcinoma cells," scientists writing in the journal Plos One report.
"Strikingly, the p73 binding profile is indistinguishable from the previously described binding profile for p63 in...
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