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American Cancer Society, Atlanta

 Giardia lamblia messenger RNA might contain dimethylguanosine caps

"Tgs1 is the enzyme responsible for converting 7-methyl-guanosine RNA caps to the 2,2,7-trimethylguanosine cap structures of small nuclear and small nucleolar RNAs. Whereas budding yeast Saccharomyces cerevisiae and fission yeast Schizosaccharomyces pombe encode a single Tgs1 protein, the primitive eukaryote G. lamblia encodes two paralogs, Tgs1 and Tgs2.

"Here we show that purified Tgs2 is a monomeric enzyme that catalyzes methyl transfer from AdoMet (K_m of 6 mcM) to m⁷GDP...

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