Published in Cancer Law Weekly, August 12th, 2006
According to recent research from the United States, "Hepatocellular carcinoma (HCC) is the third most common cause of cancer death worldwide. Improved treatments for advanced HCC are urgently needed."
"The recently identified human SULF1 desulfates cell surface heparan sulfate glycosaminoglycans and down-regulates cell growth signaling in HCC cells in vitro. While investigating the epigenetic regulation of SULF1, we discovered that histone H4 acetylation is up-regulated by SULF1 in HCC cells," said J.P. Lai and colleagues, Mayo Clinic.
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