Virology

Retrovirus involved in tumor progression studied in vivo

Published in Cancer Law Weekly, November 18th, 2006

A study from France has reported on the mobility and integration sites of a murine C57BL/6 melanoma endogenous retrovirus involved in tumor progression in vivo.

"Tumor development is a multistep process in which both genetic and epigenetic events cooperate for the emergence of a malignant clone with metastatic properties," wrote J. Pothlichet and colleagues, Institute Gustave Roussy.

"The possibility that endogenous retroviruses promote the expansion of a neoplastic clone by subverting immunosurveillance has been proposed and recently demonstrated in the case of the B16 murine melanoma, which spontaneously express the melanoma-associated retrovirus...

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Source: Cancer Law Weekly (2006-11-18)

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