Acute Myeloid Leukemia
Presence of FLT3 mutations does not impair stem cell mobilization
Published in Cancer Law Weekly, November 18th, 2006
"Fetal liver tyrosine kinase 3 (FLT3) mutations represent a powerful prognostic indicator in acute myeloid leukemia (AML). Further, interaction between FLT3 and its ligand plays a role in normal hematopoiesis.
"Accordingly, FLT3 mutations may affect mobilization of peripheral blood stem cells (PBSCs) and feasibility of autologous stem cell transplantation (ASCT) in AML," wrote investigators in the journal Biology of Blood and Marrow Transplantation.
According to F. Ferrara and colleagues at Cardarelli Hospital in Naples, "We analyzed the effect of FLT3...
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Source: Cancer Law Weekly (2006-11-18)
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