Tissue Engineering
Research from San Raffaele Scientific Institute has provided new information about tissue engineering
Published in Cancer Law Weekly, December 23rd, 2006
New investigation results, "Spontaneous formation of L-isoaspartate and gain of function in fibronectin," are detailed in a study published in Journal of Biological Chemistry. "Isoaspartate formation in extracellular matrix proteins, by aspartate isomerization or asparagine deamidation, is generally viewed as a degradation reaction occurring in vivo during tissue aging. For instance, non-enzymatic isoaspartate formation at RGD-integrin binding sites causes loss of cell adhesion sites, which in turn can be enzymatically "repaired" to RGD by protein-l-isoAsp-O-methyltransferase," investigators in Milan, Italy report.
"We show here that isoaspartate formation is also a...
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Source: Cancer Law Weekly (2006-12-23)
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