Cancer Therapy

Pair of microRNA molecules controls a major oncogene in most common leukemia

Published in Cancer Law Weekly, January 13th, 2007

Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world.

Their findings, published in Cancer Research, demonstrate that miRNAs are emerging as powerful regulators of gene expression in cancer development, and could offer new targets for drug treatment, the investigators say.

In this case, high levels of two miRNAs known as miR-29 and miR-181 seem to suppress expression of the TCL1 oncogene that drives the most aggressive forms of the leukemia, said the study's...

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Source: Cancer Law Weekly (2007-01-13)

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