Published in Cancer Law Weekly, August 16th, 2008
"It is also an overexpressed oncoprotein that mediates carcinogenesis by stabilizing the compromised structures of mutant and/or overexpressed oncogenic kinases. Recent work shows that such dependency of malignant cells on increased CDC37 expression is a vulnerability that can be targeted in cancer by agents that deplete or inhibit CDC37," wrote P.J. Gray and colleagues, Harvard University, Medical Department.
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