Researchers from University of Toronto, Department of Medicine detail new studies and findings in the area of life sciences

A new study, 'Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin,' is now available. "The bipartite transcription factor beta-catenin/TCF (cat/TCF) has been recognized as the major effector of the Wnt signaling pathway for more than a decade, and its over-activation has been associated with malignancy such as colon and breast cancer. Extensive examination in different cell lineages has shown that the activity of cat/TCF can be stimulated by mechanisms other than via the Wnt glycoproteins, including the stimulation of beta-cat nuclear translocation and enhanced binding of cat/TCF to the Wnt target gene promoters by insulin and insulin-like growth...

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