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Prostate-Specific Antigen

Studies from V.Y. Dudkin et al have provided new data on prostate-specific antigen

Published in Cancer Law Weekly, November 29th, 2008

"Prostate specific antigen (PSA) molecules secreted by cancerous and normal prostate cells differ in their N-linked glycan composition, while the peptide backbone appears to be conserved," scientists in the United States report.

"Antibodies selectively recognizing such differentially glycosylated PSA structures could form a basis for a new diagnostic assay for prostate cancer. Twenty-amino acid PSA fragments carrying di-, tri-, and tetrabranched complex-type glycans were prepared by total synthesis and conjugated to maleimide-modified keyhole limpet hemocyanin (KLH) carrier protein through backbone Cys residues," wrote V.Y. Dudkin and colleagues.

The...

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