Melanoma
Studies from V.O. Melnikova and co-researchers yield new data on melanoma
Published in Cancer Law Weekly, December 12th, 2009
According to recent research published in the Journal of Biological Chemistry, "The cellular and molecular pathways that regulate platelet activation, blood coagulation, and inflammation are emerging as critical players in cancer progression and metastasis. Here, we demonstrate a novel signaling mechanism whereby protease-activated receptor 1 (PAR1) mediates expression of melanoma cell adhesion molecule MCAM/MUC18 (MUC18), a critical marker of melanoma metastasis, via activation of platelet-activating factor receptor (PAFR) and cAMP-responsive element-binding protein (CREB)."
"We found that PAR1 silencing with small hairpin RNA inhibits MUC18 expression in...
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Source: Cancer Law Weekly (2009-12-12)
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