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Vaccinia Immunotherapy

Scientists at University of Texas, Cancer Center detail research in vaccinia immunotherapy

Published in Cancer Law Weekly, February 13th, 2010

Researchers detail in '5T4-modified vaccinia Ankara: progress in tumor-associated antigen-based immunotherapy,' new data in vaccinia. According to recent research from the United States, "IMPORTANCE OF THE FIELD: The expression and biology of the tumor-associated antigen (TAA) 5T4 suggest it is an effective target for cancer immunotherapy. AREAS COVERED IN THIS REVIEW: Development of a vaccine comprising highly attenuated modified vaccinia Ankara virus encoding 5T4 (MVA-5T4, a.k.a. TroVax)."

"WHAT THE READER WILL GAIN: Preclinical studies demonstrated that MVA-5T4 is safe and effective in prophylactic and active treatment of syngeneic murine tumor models. Over 700 doses...

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