Mutant p53
Researchers identify small molecules that can reactivate mutant p53
Published in Cancer Vaccine Week, November 10th, 2003
According to a study from Sweden, "Around half of all human tumors carry mutant p53.
"This allows escape from p53-induced cell cycle arrest and apoptosis. Many tumors express mutant p53 proteins at elevated levels," wrote V.J.N. Bykov and colleagues, Karolinska Institute, Department Oncology & Pathology.
"Restoration of wild-type p53 function should trigger massive apoptosis in tumor cells and thus eradicate tumors. Various types of small molecules have been identified that can restore native conformation and wild-type function to mutant p53," the researchers...
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Source: Cancer Vaccine Week (2003-11-10)
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