Ovarian Cancer

Raf is necessary for Ras transformation of ovarian epithelial cells

Published in Cancer Vaccine Week, March 8th, 2004

Researchers find that, in contrast to other epithelial cell types, Raf is a major effector for Ras transformation of ovarian epithelial cells."

"According to a study from the United States, "Oncogenic Ras mediates its actions through activation of multiple downstream effector signaling cascades, which in turn regulate transcription factor activation and cause changes in gene expression."

"However, there exist striking cell type differences in effector pathways that are activated by Ras, in which effectors are sufficient or necessary to promote Ras oncogenesis, and in the gene targets of Ras transformation. Therefore, we evaluated the contribution of...

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Source: Cancer Vaccine Week (2004-03-08)

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