Cancer Vaccine

JNK inhibitor rescues melanoma-specific T cells from cell death

Published in Cancer Vaccine Week, January 31st, 2005

An inhibitor of JNK can rescue melanoma epitope-specific cytolytic T lymphocytes from activation-induced cell death.

"Activation-induced cell death (AICD) as well as programmed cell death (PCD) serve to control the expansion of activated T cells to limit untoward side effects of continued effector responses by T cells and to maintain homeostasis. AICD of T cells in tumor immunotherapy can be counterproductive, particularly if the activated T cells undergo apoptotic death after the very first secondary encounter of the specific epitope. We examined the extent to which tumor epitope-specific CTLs that are activated and expanded in an in vitro-matured dendritic cell-based...

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Source: Cancer Vaccine Week (2005-01-31)

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