Apoptosis

Apoptosis induced in prostate cancer cells by pachymic acid from Poria cocos

Published in Cancer Vaccine Week, September 5th, 2005

Pachymic acid (PA), isolated from Poria cocos, could induce apoptosis in prostate cancer cells.

"PA is a natural triterpenoid known to inhibit the phospholipase A2 (PLA²) family of arachidonic acid (AA)-producing enzymes. PLA² is elevated in prostatic adenocarcinoma and conversion of AA to prostaglandins leads to AKT pro-survival activity," investigators in the United States reported.

"In this study, we investigated the effect of PA on the growth of human prostate cancer cells. PA significantly reduced cell proliferation and induced apoptosis in a dose- and time-dependent fashion, with androgen-insensitive DU145 prostate...

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Source: Cancer Vaccine Week (2005-09-05)

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