Cancer Therapy

YM529 may inhibit cancer cell invasion into the bone matrix by repressing the expression of CXCR-4

Published in Cancer Vaccine Week, November 28th, 2005

YM529 may inhibit cancer cell invasion into the bone matrix by repressing the expression of CXCR-4 in bone metastasis lesions.

According to a study from Japan, "Bisphosphonates are useful for the treatment of prostate cancer bone metastasis. However, the role of bisphosphonate on the development of the osteoblastic component of prostate cancer bone metastases is not defined."

"In the present study, the third-generation bisphosphonate, YM529 (minodoronate), was tested for its effects on the osteolytic PC-3 and novel osteoblastic LNCaP-SF cell lines," explained S. Miwa and colleagues, Kanazawa University.

"YM529 inhibited both...

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Source: Cancer Vaccine Week (2005-11-28)

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