Cancer Vaccine

Virulizin activates NK cells through IL-12 expression in macrophages

Published in Cancer Vaccine Week, November 28th, 2005

Virulizin, a novel immunotherapy agent, activates NK cells through induction of IL-12 expression in macrophages.

"Virulizin, a novel biological response modifier, has demonstrated significant antitumor efficacy in a variety of human tumor xenograft models including melanoma, pancreatic cancer, breast cancer, ovarian cancer and prostate cancer. The significant role of macrophages and NK (Natural killer) cells was implicated in the antitumor mechanism of Virulizin where expansion as well as increased activity of macrophages and NK cells was observed in mice treated with Virulizin. Depletion of macrophages compromised Virulizin-induced NK1.1+ cell infiltration into...

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Source: Cancer Vaccine Week (2005-11-28)

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