Lymphoma Vaccine
Oncolytic measles virus in cutaneous T-cell lymphomas mounts antitumor immune responses
Published in Cancer Vaccine Week, November 28th, 2005
According to recent research from Switzerland, "Some cutaneous T-cell lymphomas (CTCLs) clonal T cells are deficient in interferon signaling, making them promising targets for viral oncolysis. We evaluated cytopathic effects of measles virus (MV) in CTCL. CTCL cell lines and infiltrating lymphocytes in CTCL expressed MV receptors CD150 and CD46."
"In a phase 1 dose escalation trial a total of 16 injections of live MV, Edmonston-Zagreb vaccine strain, were given intratumorally to five patients with CTCL....
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Source: Cancer Vaccine Week (2005-11-28)
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