Apoptosis
3-Hydrogenkwadaphnin induced apoptosis in human leukemia cell lines
Published in Cancer Vaccine Week, November 28th, 2005
"3-HK is a recently characterized daphnane-type compound isolated from Dendrostellera lessertii with high antitumor activity in animal models. Herein, we report on time- and dose-dependent effects of this compound on growth, differentiation, IMPDH inhibition, cell cycle and apoptosis of a panel of human leukemia cell lines (HL-60, K562 and Molt4)," scientists writing in the International Journal of Biochemistry & Cell Biology reported.
"The drug decreased the growth of leukemia cells in <24 h of treatment. However, longer exposure times and/or higher...
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Source: Cancer Vaccine Week (2005-11-28)
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