Human Papillomavirus Vaccine
CD8+ T cells from DNA vaccine control tumors through Fas-FasL pathway
Published in Cancer Vaccine Week, January 9th, 2006
According to a report from Taiwan, "Human papillomavirus, particularly type 16, and its oncogenic proteins, E6 and E7, are consistently expressed in most cervical cancers. One of the major issues facing cancer immunotherapy is that many human cancers evade the immune system by down-regulating the expression of Fas molecules."
"An E7-expressing murine tumor model with a down-regulated Fas expression - TC-1 P3(A15) tumors - was created. A DNA vaccine encoding calreticulin linked to E7 (CRT/E7) was able to generate protective and therapeutic...
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Source: Cancer Vaccine Week (2006-01-09)
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