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Melanoma

Immune response to at least two melanoma peptides improves long-term outcomes

Published in Cancer Vaccine Week, August 28th, 2006

Immune response to at least two melanoma peptides improves long-term outcomes in patients with metastatic melanoma vaccinated with melanoma peptide-pulsed CD34+ progenitor-derived dendritic cells

According to a study from the United States, "Between March 1999 and May 2000, 18 HLA-A*0201+ patients with metastatic melanoma were enrolled in a phase I trial using a dendritic cell (DC) vaccine generated by culturing CD34+ hematopoietic progenitors. This vaccine includes Langerhans cells."

"The DC vaccine was loaded with four melanoma peptides (MART-1/MelanA, tyrosinase, MAGE-3, and gp100), influenza matrix peptide (Flu-MP), and keyhole limpet hemocyanin...

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