Hematopoietic/Progenitor Cells

AAV Vector System May Enable Transduction of Stem Cells

Published in Cancer Weekly, February 20th, 1995

By using the adeno-associated virus 2 (AAV) vector system, it is possible to achieve high efficiency transduction of primary hematopoietic stem and progenitor cells, a researcher from Indiana suggested.

Arun Srivastava, Indiana University School of Medicine, Indianapolis, noted that researchers recently have shown interest in AAV-based vectors. Unlike the more commonly used retroviral vectors, parvovirus-based vectors may become a useful alternative in gene therapy ("Parvovirus-Based Vectors for Human Gene Therapy," Blood Cells, 1994;20:531-538).

Srivastava noted that AAV, a parvovirus of human origin, is nonpathogenic, and site-specific integration...

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Source: Cancer Weekly (1995-02-20)

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