Melanoma - gp75 Antigen
"Identification of a Gene Encoding a Melanoma Tumor Antigen Recognized by HLA-A31-Restricted Tumor-Infiltrating Lymphocytes."
Published in Cancer Weekly, March 6th, 1995
According to the authors' abstract of an article published in Journal of Experimental Medicine, "The availability of antitumor cytotoxic T lymphocytes which can be generated from either peripheral blood lymphocytes after stimulation in vitro or tumor infiltrating lymphocytes (TIL) has made it possible to identify a number of melanoma antigens presented by major histocompatibility complex class I molecules. The present and previous studies indicated that TIL586 recognized an antigen expressed on most melanoma and normal melanocytes in the context of the HLA-A31 molecule. We report here the cloning of a cDNA that directs the expression of the shared melanoma antigen recognized by this TIL....
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Source: Cancer Weekly (1995-03-06)
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