Drug Resistance - Ascorbic Acid-Sensitivity
"Potentiation of Growth Inhibition Due to Vincristine by Ascorbic Acid in a Resistant Human Non-Small Cell Lung Cancer Cell Line."
Published in Cancer Weekly, March 13th, 1995
According to the authors' abstract of an article published in European Journal of Pharmacology - Environmental Toxicology and Pharmacology Section, "A human cell subline (PC-9/VCR) resistant to vincristine was established from non-small cell lung cancer PC-9 cells by incremental exposure of the cells to vincristine. The resistant cells showed phenotypic resistance to vincristine (10-fold), colchicine (6.9-fold) and cisplatin (1.4-fold) but they showed sensitivity to other chemotherapeutic agents including melphalan and etoposide VP-16. The characteristics of the vincristine resistance was partially inhibited (5-7-fold) by co-treatment of PC-9/VCR cells with a nontoxic concentration of...
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Source: Cancer Weekly (1995-03-13)
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